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TAFs interact with stromal cells by secreting growth factors, cytokines, and chemokines, including IL6, TGF, and CCL2, to amplify immune evasion systems, attracting immunosuppressive cells into the tumor microenvironment, and they also form a network of proinflammatory mediators at the tumor site

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2018;41:S1S159

By enhancing autophagy, spermidine may support longevity, reduce inflammation, and contribute to healthier ageing across tissues

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