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An oxidant/antioxidant imbalance characterized by oxidative stress and low GSH levels is involved in the pathogenesis of idiopathic pulmonary fibrosis, since data show marked GSH deficiency in the lower respiratory tract of those patients (127)

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Reduction of ScGrx7 by GSH is slower than the oxidation by GSSCys (unless Lys105 is replaced, which decelerates the oxidative half-reaction even more than the reductive half-reaction owing to the dual activator function)

Intracellular Redox-Modulated Pathways as Targets for Effective Approaches in the Treatment of Viral Infection

122 StaplesM.AcostaS.TajiriN.PabonM.KanekoY.BorlonganC

Nat Rev Immunol (2021) 21(4):24556