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These drugs or diseases increase the excretion of carnitine in the form of acylcarnitine in urine, reduce renal tubule reabsorption and endogenous biosynthesis, and inhibit carnitine transporters, resulting in increased carnitine consumption (73, 74)

If there is no causal relationship between the potential mediator and the outcome, it is unlikely that the causal effect from exposure to outcome is mediated by this potential mediator

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Gut-derived butyrate exhibits multimodal neuroprotective effects in preclinical AD models: beyond the HDAC inhibition and anti-inflammatory actions described in section 4.3, butyrate directly inhibits A fibrillization in vitro and modulates microglial phenotype toward an anti-inflammatory state