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Int Immunopharmacol (2012) 12:5436

New Drug Therapy

"This makes psychiatrists like me interested in what else activation of these receptors can do, and one of the main areas of interest is motivation." Mansur called motivation a "key clinical problem in depression, which is not only feeling low and sad, its as much about losing motivation and interest in things." Existing treatments for depression do not address that combination, he said