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2 Introduction In recent years, chronic kidney disease (CKD) incidence has doubled among older individuals, owing partly to increasing prevalence of conditions such as diabetes and hypertension that damage the delicate blood vessels of the kidneys (Liu 2010)

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Why This Matters in MCAS Many MCAS patients present with: Abdominal pain with hypersensitivity quality Post-prandial flares IBS-like patterns Burning GI discomfort without structural pathology Persistent symptoms despite antihistamines and mast cell stabilizers In these scenarios, symptoms may reflect mast cellnerve cross-talk rather than uncontrolled mediator release alone