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A method of preventing dementia in a patient with Parkinson's disease or of improving or restoring cognitive function of a patient with Parkinson's disease, comprising the step of administering to said patient an amount of one or more hepatocyte growth factor mimics sufficient to prevent, improve or restore to normal said cognitive function, said one or more hepatocyte growth factor mimics having a general structural formula 1 2 3 where Ri is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine

DPP-4 activity remained suppressed at 210 minutes after gavage of sitagliptin (180 minutes after olive oil gavage) (Figure 1B)

** The result dependson individual metabolism

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40:1479-1485 [PMC free article: PMC5652593] [PubMed: 28827404] 220