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doi: 10.1002/oby.70120 Retrieved from U.S

Seven days after a dose, around 44% of that dose's peak remains, and accumulation across weekly doses keeps steady-state levels high enough to stay pharmacologically active throughout the week

Semaglutide is a GLP-1 receptor agonist (one-hormone target)

In addition to being a glucagon-like peptide-1 (GLP-1) receptor agonist, tirzepatide is also a glucose-dependent insulinotropic polypeptide (GIP) receptor

Patients experiencing this may prefer evening administration to avoid daytime lethargy affecting work or daily activities

This is perhaps the most psychologically challenging aspect of the washout period