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This is particularly noticeable during periods of rapid weight loss, typically months 2 through 6 of treatment when youre losing 2 to 4 pounds weekly or more

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Brand pens like Ozempic and Wegovy come pre-filled and skip this step

If your semaglutide pen was left at room temperature overnight, it should still be okay as long as it hasn't exceeded the temperature limits (86F) and you're within the 6-8 week usage window after first opening

Polycystic ovary syndrome (PCOS) : Approximately 4080% of women with PCOS are overweight or obese