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Studies have shown a high incidence of males suffering from AR in children, while females have a higher chance of experiencing AR in adolescence (Varshney and Varshney, 2015)

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The vitamin has low toxicity, so supplementation carries minimal risk, but also likely provides no benefit if stores are adequate

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However, further research is essential to confirm its benefits and optimize dosage, and individuals should consult healthcare providers to ensure safe use

High-dose methotrexate-induced fulminant hepatic failure and pancytopenia in an acute lymphoblastic leukaemia paediatric patient