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Stanford suggests considering the following alternatives: Phentermine/topiramate ER (which has stronger efficacy and is FDAapproved for long-term use) GLP1 receptor agonists (e.g., semaglutide) Dual GLP1/GIP agonists (e.g., tirzepatide) Naltrexone/bupropion Orlistat in select cases The bottom line on phentermine for weight loss Phentermine can be an effective, affordable option for jump-starting weight loss, especially if you need short-term appetite support and pair it with a healthy diet and exercise