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The highest dose tested (250 mg/kg) was associated with a plasma exposure (C ave, ss ) 38 or 18 times that in humans at the recommended human dose (RHD) for migraine (120 mg) or episodic cluster headache (300 mg), respectively

doi: 10.1016/j.bbrc.2019.10.006 131 HansonLRRoeytenbergAMartinezPMCoppesVGSweetDCRaoRJet al

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NTS neurons-derived GLP-1 appears to reach out to multiple locations within the central nervous system (CNS), which have been proven to express the receptor, and be activated after a central administration of GLP-1 receptor agonists

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There, they damage cells that produce intrinsic factor