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Schretlen DJ, Pena J, Aretouli E, Orue I, Cascella NG, Pearlson GD et al

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Immunofluorescence and ELISA further demonstrated the intracellular colocalization of BPC157 with FBXO22 (Fig

KH815 has been shown to produce a more potent antitumor effect than single TOPI inhibitor-TROP2-targeting ADCs as well as the ability to overcome drug resistance in preclinical cancer models, and is currently being investigated in a phase I clinical trial in patients with advanced solid tumors (NCT06885645) 237