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The total amount of protein was determined using a BCA protein assay kit (Beyotime, Shanghai, China)

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Exendin-4 increases E2F1 transcriptional activity These data led us to postulate that GLP1R activation through an exendin-4 treatment could increase E2F1 transcriptional activity, since the E2f1 target gene expression is strongly controlled by the phosphorylation status of pRb (21)