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A dedicated medical team can provide proactive strategies to manage these issues, from dietary tips to supportive medications

Pioneer 7: This trial compared the efficacy of semaglutide (flexible dosing) and sitagliptin (fixed dose) on 504 subjects with modest kidney dysfunction receiving once-daily oral semaglutide (253) with individualized flexible dosing, or once-daily oral 100 mg sitagliptin (251)

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Individual tolerance and previous side effects: Patients who experienced significant gastrointestinal side effects when initially starting tirzepatide may require a more gradual reintroduction

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