Avoid freezing, repeated warming, or leaving the vial at room temperature for long periods, as these can reduce peptide stability
Studies have found that people with overweight or obesity may have a reduction in incretin effects, particularly if they have had frequent weight fluctuations due to yo-yo dieting or if you have undergone bariatric surgery and had weight regain
Moreover, the nanoDSF-derived T m values obtained for the designed GLP-1 albumin fusions (56.457.4 C) were comparable to that of Tanzeum (58.8 C) (Table 2, Supplementary Fig
But for peptides with known Asn-Gly sequences, extra vigilance is warranted
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doi: 10.1016/s0140-6736(08)61246-5 115 FonsecaVADevriesJHHenryRRDonsmarkMThomsenHFPlutzkyJ