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Biolayer interferometry assays showed that the sybodies bound to TGP with affinities in the range of 3.310.4 nM (Fig
& Charbit, A
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Increased AMP levels activate Adenosine Monophosphate-Activated Protein Kinase (AMPK), which contributes to lowering of glucose production by at least 2 pathways: i) increased AMPK phosphorylates CBP & CRTC2 transcription factors, which inhibits genes involved in the production of glucose (gluconeogenic genes)
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