Medication adjustments might be made at these follow-ups, although youll have access to your provider between appointments should issues or questions arise
Best-known for: potent metabolic/weight outcomes for many patients, though individual response and tolerability vary
Updated June 2026 Clinical data & FDA See all Retatrutide Phase 3 Results 2026: TRIUMPH Trial Tracker Living tracker of every retatrutide trial TRIUMPH-1/2/3/4/5, TRIUMPH-Outcomes, TRANSCEND-T2D-1/2, and SYNERGY-OUTCOMES Phase 3 readouts
How to manage it: Stay hydrated with water or electrolyte-enhanced fluids
Tirzepatide works by activating two hormone pathways (GIP and GLP-1) that help regulate blood sugar levels and appetite
GLP-1 receptor activation suppresses appetite through signaling in the hypothalamus, delays gastric emptying so you feel full longer, and improves insulin secretion