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Notably, cancer cells, with their elevated oxidative stress, exhibit heightened sensitivity to GSH deficiency, presenting a critical vulnerability exploitable in cancer therapy [11, 12]

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People with this chronic, progressive neurological disorder have high levels of oxidative stress and premature cellular die off in a part of the brain called the substantia nigra

As GSH has a net negative charge at physiological pH, the high concentration of mGSH implies the existence of specific transport systems that work against an electrochemical gradient (Griffith and Meister, 1985