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In a 72-week study enrolling 3,172 overweight adults, the highest dose of orforglipron (36 mg) caused 12.4% weight loss

Measurements of worse eyes were used for statistical analysis, i.e., higher pRNFL thickness as a marker of oedema and lower GCL volume as a marker of neuroaxonal loss

Mar 2020;37(3):414-424

Topiramate is used for weight loss and is also used off-label and endorsed by the American Psychiatric Association as a second-line treatment for AUD [25]

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