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In the trial, 751 adults with obesity or overweight plus at least one weight-related condition were randomly assigned to either Mounjaro or Wegovy for 72 weeks

In central sensitization, the spinal cord and brain amplify incoming signals regardless of their original intensity

For perimetry, we performed automated visual field testing (Humphrey Field Analyzer, Carl Zeiss Meditec, Jena, Germany) using 302 Swedish Interactive Threshold Algorithm (SITA) standard protocols, quantifying the mean deviation in decibels (dB) of all test locations compared to age-matched controls and defining abnormal perimetry as a mean deviation lower than -2 dB

What were learning is that their effects may not be limited to the stomach and digestive system. Because the medications affect pathways involved in appetite, glucose metabolism, and inflammation, researchers are studying whether they may also influence certain functions within the brain

It is characterized by impaired glycemic metabolism leading to vascular and neuronal complications, in part due to the activation of several pathways inducing oxidative stress and mitochondrial damage ( This review focuses on the data available on the effects of the new antidiabetic drugs on the HPG axis