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Despite the GLP-1 label, they generally do not produce clinically meaningful weight-loss effects, she said

However, Girardi et al

Around 30 percent of the semaglutide group lost 20 percent or more of their body weight, compared with 3 percent on placebo (Wharton et al., 2025)

Why it matters: In Eli Lillys Phase 2 trial, the highest dose produced 24.2% mean weight loss at 48 weeks the largest reduction ever reported for an anti-obesity drug at this stage

Front Neurosci 18:1527842 Zappia KJ, Erickson CA (2025) Psychopharmacology in autism

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