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As a glutathione precursor it replenishes hepatic glutathione, which conjugates the reactive toxic metabolite of acetaminophen (paracetamol) and scavenges oxidant radicals

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NICE does not currently recommend either supplement for weight management, and they are not part of standard NHS obesity treatment pathways, which emphasise lifestyle modification, behavioural support, and where appropriate, licensed medications such as orlistat or semaglutide (Wegovy) within specialist services according to NICE guidance

Also, the type of magnesium matters

Establish baseline kidney function, hydration habits, and protein intake before starting creatine

However, there is a lack of evidence regarding the specific methods and frequency of testing