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Off-Label Drug Use in Canada Health Canada: Regulatory position on off-label prescribing by licensed Canadian physicians

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Younger individuals with a significant family history or other predisposing factors may warrant earlier or more intensive screening protocols

Specifically, the evidence base for the maintenance effect of lithium in bipolar disorder is far stronger than for any other drug [12, 39-41], comprising at least 21 RCTs comparing lithium with other drugs or placebo [39] in addition to a total study base of 71 studies (N = 30,542) [41]

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