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Psychol Sci 2015;26:750-8

The preclinical data is promising, but individual human responses vary dramatically

Another miRNA shown to regulate Nrf2 is miR-34, able not only to target NFE2L2 but also downstream genes involved in cellular response to OS, such as microsomal glutathione S-transferase 1 ( Mgst1 ) and Sirtuin 1 ( Sirt1 ) genes in rat liver during aging [226]

Thus, RBC, which have a nominal ability for de novo protein synthesis, may accumulate oxidized proteins (69), including those necessary for maintaining NADPH stores (Fig