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Ferroptosis, characterized by dysregulated iron metabolism and lipid peroxidation, is an autophagy-dependent form of cell death that plays a vital role in oxidative stress

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In a study with 60 high-risk primigravida (due to abnormal uterine artery Doppler waveform), randomly divided (1:1) into two groups to take either 100 g selenium supplements or the placebo from 17 to 27 weeks of gestation, a higher proportion of women with UtA PI 1:100) were identified and randomized to aspirin vs

Mechanistically, we further show that tBHP induces GSH depletion as well as GPX4 downregulation in cardiomyocytes, leading to GPX4 inactivation and elevated lipid peroxidation

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