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There are also philosophical conversations regarding pharmaceutical use for weight management that have continued over the yearsanyone remember the Fen-Phen days of the 90s

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Importantly, in these and other clinical trials, the safety profile of GLP-1 receptor agonists was well established

International Journal of Molecular Sciences , 22 (12), 6623

GLP-1 users are eating less overall and shifting toward healthier eating habits

The concept of microdosing reportedly dates back to the 90s, when it was part of clinical drug development, before it was adopted by psychedelics users (and then GLP-1 users)