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Unlike conventional chemotherapy, which non-selectively kills rapidly dividing cells, targeted therapies aim to minimize harm to normal tissues by focusing on tumor-specific molecular alterations (e.g., HER2 amplification, ALK rearrangements)

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In this study, when the protein profile of the liver and kidney was investigated with SDS-PAGE, MTX did not change the liver protein profile, but it caused a decrease in some protein bands in the kidney tissue

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TABLE 2 Co-chaperones of HSP70 family

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