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Beyond hemolysis, recent evidence suggests a role for microvesicle formation and mitochondrial retention in oxidatively-stressed RBCs in potentiating immune activation (75, 76)

As molecular weight roughly doubles from 1,000 to 2,000 Da, passive permeability across mucosal membranes typically drops by an order of magnitude or more, based on established membrane permeability principles

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Gently swirl until dissolved (10-20 minutes)

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Beuming T et al (2008): The binding sites for cocaine and dopamine in the dopamine transporter overlap