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Pharmacologic Overview of GLP-1 Receptor Agonists Mechanism of Action Endogenous GLP-1 is an incretin hormone secreted by intestinal L-cells postprandially

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Microdosing semaglutide, using doses below the standard therapeutic range, has gained attention as an approach for people who want modest appetite suppression with minimal side effects

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[13] [14] [15] [26] [36] [15] to reduce excess body weight and maintain weight reduction long term in obese individuals twelve years of age or older, or for overweight adults with at least one weight-related comorbid condition

The STEP-HFpEF and STEP-HFpEF DM trials evaluated the efficacy of weekly semaglutide treatment versus placebo in patients with obesity-related HFpEF, both with and without diabetes, respectively