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For baseline protocols in untrained subjects, it's overkill

[12] [16] They are active over a wide variety of substrates with considerable overlap

Summary Keywords aging, chronobiology, chrononutrition, circadian rhythm, dietary and lifestyle interventions, melatonin, molecular clocks, sleep Citation Drgoi CM, Dumitrescu I-B and Nicolae AC (2026) Rhythms of life: melatonin, nutrition, sleep, and antioxidant strategies for healthy aging

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The oral version requires a 30-to-60-minute window of no food or coffee after waking up

Strijbis K, Vaz FM, Distel B