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Previous research suggesting GLP-1 drugs might influence aging came from laboratory or animal studies or from observational data

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Mechanism of Action Metformin decreases hepatic glucose production and improves hepatic insulin sensitivity but has only a modest impact on peripheral insulin-mediated glucose uptake (i.e., insulin resistance), which is likely due to a reduction in hyperglycemia, triglycerides, and free fatty acid levels (48,49)

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The FDA has approved branded versions of these medications (Wegovy, Ozempic, Mounjaro, Zepbound) for specific indications, but compounded versions are legally distinct products prepared by compounding pharmacies under federal and state regulations