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In 2023, Juan P Frias and colleagues, in The Lancet, published the first phase two clinical trial of orforglipron, which investigated the use of a small-molecule oral GLP-1R agonist called orforglipron in type 2 diabetes, which can be taken at any time of the day without restrictions on food and water intake (Frias et al., 2023)

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Mechanistically, depletion of GSH stores in untransformed human T-cells cells was indeed accompanied by increased oxidation of proteins at redox active cysteine residues