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Because vaginal endpoints are not systematically collected or reported as key outcomes in major semaglutide trials in publicly available labelling, much of the question depends on indirect evidence and signal detection

TRIUMPH-1 the pivotal general obesity trial with 2,339 patients followed for 80 weeks also reported dysesthesia, confirming this side effect occurs across different patient populations, not just osteoarthritis patients

Using genetics to understand the causal influence of higher BMI on depression

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