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Nat Rev Nephrol 16(1):5164

These drugs can improve metabolic health, reducing inflammation and insulin resistance, which are risk factors for CRC

Celebrex is available by prescription, while ibuprofen is available over the counter (OTC) in lower doses and by prescription in higher doses

doi: 10.3382/ps.2007-00325

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While it was long assumed that patients simply suffered from systemic glutathione depletion, a landmark 2025 study published in the Proceedings of the National Academy of Sciences (PNAS) uncovered a more complex reality