can retatrutide cause high blood pressure (“reta”) is an experimental weight-loss drug currently in Phase 3 clinical trials. It's a once-weekly injection similar to Ozempic and Mounjaro—but more powerful. The reason comes down to how it works Retatrutide Side Effects Guide: 21

Koole, C., Savage, E

Despite the rejection, CMS has indicated that it might cover obesity medication in future rulemaking

In a postweaning androgenization (PWA) mouse model, treatment with a GLP-1/GIP/glucagon triagonist significantly reduced ovarian weight and serum luteinizing hormone (LH) levels

On the one hand, insurers recognize the potential for GLP-1 drugs to reduce costly chronic conditions, but on the other, are wary of the sheer scale and cost of widespread adoption

Improvements in ALT and hepatic fat fraction were sustained up to 48 weeks of treatment with tropifexor, but dose-dependent pruritus was also the most common side effect (NCT02855164)

But these side effects also occur to some degree with semaglutide, without a large enough difference to favor one over the other