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This gradual titration approach is consistent with the prescribing philosophy applied to other incretin-based therapies in the UK, where slow escalation is used to improve tolerability and encourage long-term adherence

Typical dosage: 200500mcg once daily Administration: Subcutaneous, away from the injury site (for systemic circulation) Cycle length: 4+ weeks

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The g-glutamyl cycle is now believed to have a major role in higher organisms in the metabolism of leukotrienes, estrogens, prostaglandins, and many drugs and xenobiotics