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This increase in quantity may be a compensatory mechanism to compensate for functional deficits

5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Acute Lymphoblastic Leukemia Risk: A Meta-Analysis

Lee SW, Kim WJ, Choi YK, Song HS, Son MJ, Gelman IH, et al

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We note that, for purposes of identifying significant procedure codes for examination under the 2 times rule, we consider procedure codes that have more than 1,000 single major claims or procedure codes that both have more than 99 single major claims and contribute at least 2 percent of the single major claims used to establish the APC cost to be significant (75 FR 71832)

doi: 10.1007/s11523-015-0368-7