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Celastrol, a TFEB (transcription factor EB) agonist, is a promising drug candidate for Alzheimer disease

Drug Targets 9 (4), 376389

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In contrast, several polysaccharides have been proven to reduce cisplatin resistance ( Angelica sinensis polysaccharide (ASP) combined with cisplatin increased ferroptosis in cisplatin-resistant ovarian cancer cells through inhibition of GPX4 expression with significant GSH depletion and no obvious toxicity to liver, kidney, and cardiac tissues, ultimately reversed the resistance to cisplatin ( Lotus seedpod polysaccharides (LSP) combined with cisplatin induced ferroptosis in hepatocellular carcinoma via GSH-dependent pathway (Fu et al., 2021)

Inflammation can also affect the quality of the uterine environment, making sperm implantation more difficult

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