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IL-1 is a typical inflammatory mediator produced by nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3 (NLRP3) inflammasome, leading to myocardial hypertrophy, heart failure, and coronary atherosclerosis [85, 86]

Quantification of fibrosis area was performed using the ImageJ software

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591615 (Springer, 2024)

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