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These in vitro studies in monolayers with cancer-derived cell lines differ radically from the situation in vivo in the normal intact intestinal epithelium with numerous specialized cell types, intact blood and lymphatic circulations, and other structures and factors such as the glycocalyx, secreted mucus, reticuloendothelial cells, other immune cells, and mesenteric nerves

Other GLP-1 and glucagon co-agonists in early phase clinical trials as treatments for obesity include AZD9550 and LY3305677 (NCT05623839)

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