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In the serum, Fe 2+ is oxidized by ceruloplasmin to Fe 3+ and then binds with transferrin (TF) to form a TFFe 3+ complex, which is endocytosed through the cell membrane transferrin receptor 1 (TFR1) (Frazer and Anderson, 2014)

Meira de-Faria F, Bednarska O, Strm M, Sderholm JD, Walter SA, Keita V

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The most critical factor determining longevity is storage temperature - every 10C increase roughly doubles degradation rate, making freezer storage (-20C) essential for long-term powder storage and refrigeration (2-8C) mandatory for reconstituted peptides

H., DAINTY, J