High glucose levels lead to the creation of advanced glycation end products (AGEs), which contribute to fibrotic tissue formation [28], and both AGEs and excess insulin can promote fibroblast proliferation and ECM production [29,30]
Fetuin-B links nonalcoholic fatty liver disease to type 2 diabetes via inducing insulin resistance: Association and path analyses
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Supporting this view was the fact that compared with non-diabetic patients, the levels of white blood cells, creatinine and triglycerides in diabetic patients with HFpEF were higher [35]
Exercise training normalizes enhanced sympathetic activation from the paraventricular nucleus in chronic heart failure: role of angiotensin II
More than 54.6% of participants achieved 10% weight loss, alongside meaningful improvements in cardiometabolic markers, including blood pressure, waist circumference, and lipid levels
