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New England Journal of Medicine , 2002, 346:476-483

Who Should Consider Glutathione Supplementation and Provider Guidance Glutathione supplementation may be worth exploring for individuals with chronic oxidative stress (prolonged inflammation, heavy metal exposure, or certain disease states), but it should not replace evidence-based medical treatment

While this may sound impressive, none of these assertions are based on human trials

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Key highlights: Once-daily oral administration No food or water restrictions No injections required ~12% mean weight loss in Phase 3 trials Improvements in cardiometabolic risk markers Indication: Approved for adults with obesity, or overweight individuals with weight-related comorbidities, alongside reduced-calorie diet and increased physical activity