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Despite the slightly higher fresh weight of nrc1 at low AITC concentrations the mutant coped less well at the two highest doses relative to WT (Fig

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However, prolonged discontinuation may compromise glycaemic control and cause rebound appetite

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Here is a summary of the most commonly used DSIP dosing protocol based on available reports: Starting DSIP dose: 100mcg administered at night, preferably three hours before bedtime