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Most TPE treatments in the United States use the centrifugation method, which separates blood components into layers of red blood cells, plasma, platelets, granulocytes, monocytes, and lymphocytes according to density

Higher concentration doesn't automatically mean better results and can increase irritation risk

The administration of additional doses of specific vitamins may be required [see Dosage and Administration (2.2)]

Sanchez-Sanchez, R

Alterations in iron levels may therefore induce abnormal microglial activation, increasing hypersensitivity and promoting chronic neuroinflammation

doi: 10.1016/j.lwt.2018.03.009 180