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Chili with ground turkey meat and beans Burgers served on a Portello mushroom, lettuce, or just plain without a bun

A Note on Rare Genetic Obesity One further drug, setmelanotide (Imcivree) , is approved by Health Canada, but only for a small group of patients with rare genetic causes of obesity (such as Bardet-Biedl syndrome)

Despite accounting for 12.6% of global GLP-1 clinical trial activity in 2025, placing it third globally behind the US and China, prescribing rates for obesity indications remain comparatively low

Weight Loss and Metabolic Benefits One of the most widely discussed effects of GLP-1 medications is weight loss

These studies have generally demonstrated that the GLP-1 RA provided superior glycemic control and weight loss relative to the DPP-4 inhibitor