Analyses were performed over patient lifetimes (up to 50 years), as recommended in the guidelines for the cost-effectiveness assessment of interventions for type 2 diabetes, to ensure all relevant diabetes-related complications and their impact on clinical and cost outcomes were captured [19]
SREBP-1, in particular, governs the transcription of various lipogenic enzymes, including ACC, FASN, and glucose-6-phosphate dehydrogenase (6PGD), thereby playing a critical role in fatty acid biosynthesis [25]
Research has demonstrated that decreased carbohydrate intake, alongside increased protein consumption, mitigates the risk of hypoglycemia by reducing insulin secretion [60]
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