Experimental models have evaluated it for cytoprotective and regenerative activities across gastrointestinal mucosa, tendons, ligaments, muscles, bone, nervous tissue, and vascular endothelium
A meta-analysis of 15 studies and 15,498 subjects found an increased relative risk of HTN with higher circulating TMAO levels (1.14, 95% CI 1.081.20), and although the RR is relatively small for such a large sample size, this relationship was dose-dependent with a 1.014% increase in HTN risk for every increase of TMAO level by 1 mol/L [70]
The gut microbiome in autism: Study-site effects and longitudinal analysis of behavior change
10.1038/S41589-019-0462-8 124
What is the biggest side effect of GLP-1
L., & Arnoczky, S