Bottom Line Dry mouth, bad breath, and taste changes can show up with GLP-1s, even without hard proof the medication causes them directly
W., Sievers, S
Chlorogenic acid significantly reduced ROS levels and inhibited apoptosis by decreasing the BAX/BCL-2 ratio in human lens epithelial cells treated with H 2 O 2 [90]
Park HJ, Rosado JA, Redondo PC, Cho YS
Effects appear to diminish once dosing stops, given the peptide does not cause permanent changes to mitochondria
Therefore, we preformed DCFH-DA and C11-BODIPY staining followed by flow cytometry and found that WT ACTL6A reversed the increase in ROS levels (in cells treated with or without H 2 O 2 or both H 2 O 2 and NAC) and lipid peroxidation levels (in cells treated with or without erastin or both erastin and Fer-1), while ACTL6A HR-deleted mutant did not reverse these high levels (Fig