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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial
Interestingly, the same study found that, in rats, tirzepatide suppressed lipid intake without affecting sucrose (carbohydrate) consumption in a choice-based assay, implying that the effects of these medications may be macronutrient specific (Geisler et al., 2023)
"Obesity is the dysregulation of an entire body process, which is weight, causing something that should not happen," Alexander said in an interview
Once released into the bloodstream, GLP-1 acts as a hormone to influence multiple organs and systems throughout the body
Recent findings on extra-pancreatic GLP-1 receptors on liver sinusoidal endothelial cells and hepatic stellate cells help clarify these diverse effects and may explain the survival benefits noted in patients with cirrhosis
Why is this hopeful
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